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KMID : 0043320070300081047
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Archives of Pharmacal Research
2007 Volume.30 No. 8 p.1047 ~ p.1050
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Therapeutic Efficacy of DNA-Loaded PLGA Microspheres in Tumor-Bearing Mice
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Son Hye-Jung
Kim Jin-Seok
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Abstract
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In vivo gene therapy was attempted using poly-(D,L-lactic-co-glycolic acid) microspheres containing the interleukin-12 gene (p2CMVmIL12) in colon adenocarcinoma (CT-26)-bearing Balb/ c mice. Treatment with IL-12-loaded microspheres inhibited tumor growth significantly compared to a control group treated with free IL-12 DNA, though the degree of tumor inhibition was not dependent on the amount of IL-12 gene loaded. Combining gene therapy with 5-fluorouracil (50 mg/kg) treatment further inhibited tumor growth compared with gene therapy alone. The results indicate that microsphere formulations of pDNA may provide an efficient gene delivery system.
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KEYWORD
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Microsphere, PLGA, Cancer gene therapy, CT-26, 5-Fluorouracil (5-FU)
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